Bitter melon traditionally has been used as an abortive and has been documented with weak uterine stimulant activity; therefore, it is contraindicated during pregnancy.

This plant has been documented to reduce fertility in both males and females and should therefore not be used by those undergoing fertility treatment or seeking pregnancy.

All parts of bitter melon (especially the fruit and seed) have demonstrated in numerous in vivo studies that they lower blood sugar levels. As such, it is contraindicated in persons with hypoglycemia.